The Dangers of Mixing GHB & Alcohol: What To Stay Away From

ghb and alcohol

Table of Contents

Alcohol and GHB are two substances that should never be mixed, even when being used recreationally. The combination of these drugs can leave a person inebriated, vulnerable, and severely disoriented, leading to complications and lasting side effects. 

Around 76% of emergency cases regarding GHB use in the U.S. also show concurring use of alcohol.1 It is also commonly known as a date-rape drug, meaning GHB can be spiked in a victim’s drink without them knowing. This makes it clear that a focus on alcohol and GHB addiction is essential to prevent individuals from misusing the drug or falling victim to assault. 

If you or someone you know is struggling with alcohol and substance abuse, Nurture Nexus Recovery Center can provide professional addiction treatment to promote recovery.

Why It Is Dangerous to Mix GHB and Alcohol

GHB (gamma-hydroxybutyrate) is an illegal drug that is used as a CNS depressant and anesthetic in medical practice. It is abused by individuals when used recreationally for a prolonged high and enhanced pain relief. But, it is also used as a ‘party mix’ to encourage sexual intercourse and even take advantage of victims.2 

When GHB is taken with alcohol, both substances compete to complete the same metabolic pathways in the liver.3 This overwhelms the organ and hinders the body’s ability to break it down, causing toxicity levels to rise. Since they are both CNS depressants, they slow brain activity and vital body functions to dangerous limits, often causing issues in breathing and heart rate. 

Some of the most serious risks include:

  • Extreme sedation leading to loss of consciousness or coma
  • Respiratory depression, where breathing becomes dangerously slow
  • Sudden drops in blood pressure, which can cause fainting or cardiac arrest
  • Memory loss and blackouts that leave users vulnerable
  • Increased risk of assault since GHB is often used as a date-rape drug
ghb and alcohol mixing
Reasons Why People Mix GHB and Alcohol

Understanding GHB Abuse, Side Effects & Withdrawal

Although GHB occurs naturally in the body in small amounts, it is mostly procured illegally since it is marketed as “liquid ecstasy” or a “party drug”. At first, an individual who takes GHB will feel relaxed, euphoric, and even free for a few hours until a severe wave of nausea and dizziness sets in.4

People often begin using GHB to:

  • Heighten social confidence at clubs or parties
  • Improve sexual performance or pleasure
  • Promote muscle growth
  • Self-medicate for anxiety or insomnia

However, the body is quick to develop a tolerance to the drug. Within a week of consistent use, the body no longer reacts as strongly to the standard dose, and individuals begin to increase their intake to lethal levels. 

Side Effects of GHB Use

GHB has a narrow safety margin, where even the smallest milligram can cause the body to overdose in severe cases. Yet, most people are unaware of its side effects and cannot tell GHB use apart from other drug side effects.5

Common side effects include:

  • Drowsiness and dizziness
  • Confusion or disorientation
  • Vomiting and dehydration
  • Muscle spasms or tremors
  • Slurred speech and loss of coordination

Severe reactions may escalate to:

  • Seizures or convulsions
  • Slow or stopped breathing
  • Loss of consciousness
  • Coma or cardiac arrest

Once this substance is paired with alcohol addiction, it can exacerbate the side effects and lead to a potential loss of life.

What GHB Withdrawal Looks Like

Like many CNS depressants, once the body has built a tolerance to the drug, sudden changes in its use can trigger intense withdrawal symptoms.6 GHB withdrawal is often life-threatening and requires medical supervision to help the patient recover successfully.

It is essential to seek help if a patient experiences any of the following signs:

  • Anxiety, panic attacks, and restlessness
  • Tremors or muscle twitching
  • Sweating, nausea, and insomnia
  • Increased heart rate and blood pressure
  • Hallucinations or paranoia
  • Seizures in severe cases

The withdrawal process usually peaks within the first 24–72 hours but can last up to two weeks. Without proper medical care, the body’s chemical imbalance can cause severe dehydration, confusion, and, in rare cases, delirium.

 

Expert Opinion on GHB Abuse and Date Rape

“GHB is a dangerous substance that should only be used in a medical setting. Since it’s so difficult to detect in drinks, many people fall victim to accidental or intentional GHB abuse. It is essential to be aware of what you’re drinking at parties and keep your drinks safe from any unwanted additions. If you do suspect your drink has been spiked with GHB, seek medical attention immediately.”

Dr. Oluwole Popoola

 

Treatment Options For GHB & Alcohol Addiction

Many addiction treatment centers and clinics in Texas provide the following options for GHB & alcohol addiction7:

Inpatient Treatment

In case of extreme GHB poisoning, patients can be admitted for inpatient treatment where they are medically monitored. This treatment approach also includes extensive behavioral therapy sessions or 30-day alcohol rehabs to correct addictive behavior and promote sustainable recovery.

Outpatient Treatment

If you have a slight drinking problem and tend to take recreational party drugs like GHB, this treatment option will work best for you. It consists of low-intensity therapy sessions a few days a week to encourage better decision-making and can be coupled with FDA-approved medication to counter the GHB side effects.

Intensive Outpatient Treatment

An intensive outpatient treatment is effective for patients who have a severe addiction to both GHB and alcohol and tend to abuse the substances together. These structured sessions last 3-5 hours and help promote healthy coping mechanisms and prevent relapse.

Partial Hospitalization Treatment

For patients who have stable living conditions but still need a good degree of medical supervision, a partial hospitalization treatment can work well. This treatment option consists of 6-8-hour sessions daily to provide structured support and care for critical cases.

Medication-Assisted Treatment

Naltrexone and Disulfiram are the most common FDA-approved medications used for alcohol addiction treatment. Although there isn’t any approved drug for GHB addiction, many over-the-counter and prescription medications can be used to treat the nausea and disorientation-related side effects during the MAT program.

Tips For Preventing GHB Spiking in Your Drinks

GHB is a colorless and odorless substance that can’t be detected in your drink once it’s been added.8 This makes it essential to guard your drink against any possible tampering to prevent the use of such date-rape drugs.

  • Always keep your drink in sight and never leave it unattended.
  • Only accept drinks that are sealed or prepared in front of you.
  • Avoid sharing drinks or sipping from anyone else’s glass.
  • Pay attention to changes in taste or color, as GHB can make drinks taste salty or bitter.
  • Choose bottled or canned beverages that you can open yourself.
  • Use drink covers or lids designed to prevent tampering at crowded events.
  • Go out with trusted friends and stay aware of each other’s safety.
  • Watch for sudden drowsiness, confusion, or loss of balance in yourself or others.
  • Report any suspicious behavior to bar staff, security, or authorities immediately.

Nurture Nexus Recovery For Your Addiction Treatment in Texas

Using drugs recreationally or not guarding your drinks at parties can leave one vulnerable to GHB and alcohol abuse. However, Nurture Nexus Recovery Center can help you recover from an addiction to both these substances. Our team of medical experts will help you or your loved ones get started towards a better sober future. Call us at (214) 838-7488 or contact us to book an appointment today.

Frequently Asked Questions

Can Mixing Alcohol & GHB Be Fatal?

Yes, mixing large quantities of GHB with alcohol can have fatal complications that can cause death within a couple of minutes. It is essential to look out for signs of GHB overdose and call emergency services immediately.

How Do I Help Someone Who’s Had Too Much Alcohol With GHB?

One of the best ways to help someone who you suspect has mixed GHB with alcohol is to get them to stop drinking. Check them for symptoms related to slowed heart rate, restricted breathing, and disorientation. If symptoms persist, seek medical help as soon as possible.

Are There Any Permanent Effects of GHB Poisoning?

Yes, if GHB is administered in large doses along with alcohol, it can cause permanent damage to memory, coordination, and even the respiratory system. The most common permanent side effect of GHB poisoning is memory blackouts.

Additional Resources:

  1. Expert’s Guide To Finding the Best Alcohol Addiction Treatment Near You
  2. What To Look For in a 30 Day Alcohol Rehab Near You
  3. How To Find the Best Austin Alcohol Treatment Centers
  4. Taking Trazodone And Alcohol Together? Know The Potential Dangers
  5. Can You Take Prednisone and Alcohol Together? Interactions, Metabolism, and Safety
Alcohol Addiction Treatment
Get Help If You Have Mixed GHB and Alcohol Today!
  1. Palamar JJ. Prevalence and Correlates of GHB Use among Adults in the United States. Journal of Psychoactive Drugs [Internet]. 2022 May 26 [cited 2025 Oct 10];1:1–6. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC9699895/
  2. Le JK, Richards JR. Gamma-Hydroxybutyrate (GHB, “G”, Liquid X, Liquid E, Juice, Mils, Fantasy) Toxicity [Internet]. Nih.gov. StatPearls Publishing; 2019 [cited 2025 Oct 10]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK430781/
  3. Ferrara S, Zotti S, Tedeschi L, Frison G, Castagna F, Gallimberti L, et al. Pharmacokinetics of gamma-hydroxybutyric acid in alcohol dependent patients after single and repeated oral doses. British Journal of Clinical Pharmacology [Internet]. 1992 Sep [cited 2025 Oct 10];34(3):231–5. Available from: https://pubmed.ncbi.nlm.nih.gov/1389947/
  4. Tay E, Lo WKW, Murnion B. Current Insights on the Impact of Gamma-Hydroxybutyrate (GHB) Abuse. Substance Abuse and Rehabilitation [Internet]. 2022 Feb [cited 2025 Oct 10];Volume 13(13):13–23. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC8843350/
  5. Busardo F, Jones A. GHB Pharmacology and Toxicology: Acute Intoxication, Concentrations in Blood and Urine in Forensic Cases and Treatment of the Withdrawal Syndrome. Current Neuropharmacology [Internet]. 2015 Apr 13 [cited 2025 Oct 10];13(1):47–70. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC4462042/
  6. Wolf CJH, Beurmanjer H, Dijkstra BAG, Geerlings AC, Spoelder M, Homberg JR, et al. Characterization of the GHB Withdrawal Syndrome. Journal of Clinical Medicine [Internet]. 2021 May 26 [cited 2025 Oct 10];10(11):2333. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC8199158/
  7. Röell AE, Ramnarain D, Kamal R. Successful Treatment of Severe Gamma-Hydroxybutyric Acid Withdrawal Syndrome With Dantrolene. Cureus [Internet]. 2021 Jul 14 [cited 2025 Oct 10];13(7). Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC8362866/
  8. van Amsterdam JGC, Brunt TM, McMaster MTB, Niesink RJM. Possible long-term effects of γ-hydroxybutyric acid (GHB) due to neurotoxicity and overdose. Neuroscience & Biobehavioral Reviews [Internet]. 2012 Apr [cited 2025 Oct 10];36(4):1217–27. Available from: https://pubmed.ncbi.nlm.nih.gov/22342779/

 

  1. Palamar JJ. Prevalence and Correlates of GHB Use among Adults in the United States. Journal of Psychoactive Drugs [Internet]. 2022 May 26 [cited 2025 Oct 10];1:1–6. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC9699895/
  2. Le JK, Richards JR. Gamma-Hydroxybutyrate (GHB, “G”, Liquid X, Liquid E, Juice, Mils, Fantasy) Toxicity [Internet]. Nih.gov. StatPearls Publishing; 2019 [cited 2025 Oct 10]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK430781/
  3. Ferrara S, Zotti S, Tedeschi L, Frison G, Castagna F, Gallimberti L, et al. Pharmacokinetics of gamma-hydroxybutyric acid in alcohol dependent patients after single and repeated oral doses. British Journal of Clinical Pharmacology [Internet]. 1992 Sep [cited 2025 Oct 10];34(3):231–5. Available from: https://pubmed.ncbi.nlm.nih.gov/1389947/
  4. Tay E, Lo WKW, Murnion B. Current Insights on the Impact of Gamma-Hydroxybutyrate (GHB) Abuse. Substance Abuse and Rehabilitation [Internet]. 2022 Feb [cited 2025 Oct 10];Volume 13(13):13–23. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC8843350/
  5. Busardo F, Jones A. GHB Pharmacology and Toxicology: Acute Intoxication, Concentrations in Blood and Urine in Forensic Cases and Treatment of the Withdrawal Syndrome. Current Neuropharmacology [Internet]. 2015 Apr 13 [cited 2025 Oct 10];13(1):47–70. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC4462042/
  6. Wolf CJH, Beurmanjer H, Dijkstra BAG, Geerlings AC, Spoelder M, Homberg JR, et al. Characterization of the GHB Withdrawal Syndrome. Journal of Clinical Medicine [Internet]. 2021 May 26 [cited 2025 Oct 10];10(11):2333. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC8199158/
  7. Röell AE, Ramnarain D, Kamal R. Successful Treatment of Severe Gamma-Hydroxybutyric Acid Withdrawal Syndrome With Dantrolene. Cureus [Internet]. 2021 Jul 14 [cited 2025 Oct 10];13(7). Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC8362866/
  8. van Amsterdam JGC, Brunt TM, McMaster MTB, Niesink RJM. Possible long-term effects of γ-hydroxybutyric acid (GHB) due to neurotoxicity and overdose. Neuroscience & Biobehavioral Reviews [Internet]. 2012 Apr [cited 2025 Oct 10];36(4):1217–27. Available from: https://pubmed.ncbi.nlm.nih.gov/22342779/