Long-Term Effects of Adderall® Abuse: Seek Immediate Help

Long Term Effects of Adderall

Table of Contents

The long-term effects of Adderall® abuse can cause irreversible damage to the body, including devastating outcomes like cardiac arrest and renal failure. According to the National Institute of Drug Abuse, 3.7 million people aged 12 and up abused Adderall® to lose weight, concentrate, or get high in 2021.1 

Therefore, timely intervention for Adderall® addiction treatment is essential for recovery. With proper treatment, you can avoid the long-term effects of excessive use of Adderall® and live a healthy life. If you feel you or a loved one might be developing an Adderall® addiction, Nurture Nexus Recovery can help. Call us at (214) 838-7488 or schedule an appointment.

What Are The Long-Term Effects of Adderall® Abuse?

Adderall abuse has many long-term effects on both the brain and the body. The intensity of these effects depends on how long the drug has been abused and the body’s general health condition.

Adderall® Effects on The Brain

The brain is one of the organs that is affected by Adderall use. Since it is both an amphetamine and a stimulant, it changes your brain’s chemistry, alters your mood, and causes a change in the way you think.2 Some of the most prominent long-term effects of Adderall on the brain are:

  1. Neurotransmitter Depletion: With consistent use, Adderall depletes the brain’s dopamine reserves and leads to gradual dependency.
  2. Changes to Brain Structure: Areas in the brain related to emotion and decision-making are particularly impacted by long-term Adderall use.3
  3. Increased Tolerance: After a while, the brain develops a tolerance for Adderall, which requires the user to take larger quantities of the substance to feel its effects.
  4. Issues With Cognition: Chronic Adderall abuse could slow down brain function, causing issues with cognition like memory, learning, coordination, and more.
  5. Sleep Problems: Long-term Adderall use has been linked to the development of insomnia (not sleeping enough) or hypersomnia (sleeping too much).4

Adderall® Effects on The Body

Apart from long-term effects on the brain, excessive Adderall use can also adversely affect the body. These effects may be different based on the user’s health and tolerance towards side effects. They can also continue even after treatment for prescription drug addiction. However, some of the most common effects include an impact on:

  • Cardio-Vascular Systems: Excessive Adderall use is hard on the heart and can cause increased heartbeat, a rise in blood pressure, and body temperature. Prolonged misuse may tends to weaken blood vessels and can even lead to the development of cardiac arrest.5
  • Adrenal Functioning: Adderall abuse can strain the adrenal system.6
  • Slowed Digestion: Like many stimulants, Adderall misuse may upset the stomach and slow down digestion.9 Since it impacts metabolism and stomach muscles, it can cause cramping, acid reflux, and nausea. 
adderall dosage
Adderall Dosage Guidelines for Adults and Children

Does Adderall® Have Any Short-Term Side Effects?

Adderall is a fast-working drug, which means it also has immediate short-term side effects. These side effects range from physical symptoms such as excessive sweating to emotional ones like irritability and anger.10 

Although Adderall stays in your system for a long time, its immediate side effects last for the duration of the dose. That’s why finding the right treatment center for addiction is so important. Here are seven of the most common short-term side effects of Adderall:

  • Dry mouth
  • Diarrhea
  • Increased heartbeat
  • Stomachache
  • Anxiety
  • Agitation
  • Loss of appetite 

What Does Adderall® Abuse Look Like?

Recognizing the signs of Adderall abuse can be difficult at first, especially when use is disguised as hyper-productivity or doing well academically. People who abuse Adderall often show patterns of excessive energy followed by crashes, disrupted sleep schedules, and rapid weight loss due to appetite suppression.11

You might even notice they’re acting more agitated than usual and secretive about their behavior. Long-term Adderall abuse can also look like obsessiveness related to work or studies, and a failure to deliver on days when the drug isn’t taken.

In more severe cases, people may also experience:

  • Paranoia
  • Aggression
  • Hallucination
  • Seizures

However, Adderall abuse can mirror symptoms of other stimulant addictions.12 That’s why even if you suspect someone has an Adderall addiction, only a professional can diagnose it. Once it has been diagnosed, you need to begin addiction treatment immediately.

Understanding Adderall® Overdose

An Adderall overdose is a medical emergency that can occur when someone takes too much of the drug intentionally or by accident. Some of the common signs of an Adderall overdose include tremors, chest pain, increased heartbeat, excessive sweating, disorientation, seizures, and cardiac arrest.14

These signs can be more severe and fatal if the overdose was instigated by taking the drug in combination with alcohol or substances like cocaine and other stimulants. This is why getting timely treatment for a suspected Adderall addiction is highly important.

Expert Opinion on Adderall Abuse

“Most people don’t know they’re addicted to Adderall until it’s taken over their life. They think they can stop whenever they want to. However, excessive use of Adderall changes the way your brain functions, and after long-term abuse, it becomes the new normal for your body. That’s why it’s important to get help as soon as you feel the relationship between you and Adderall is getting out of hand.”

-Dr. Oluwole Popoola

When To Get Help For Adderall® Addiction

If you suspect you or someone you love is suffering from Adderall addiction or substance use disorder, it is best to get help immediately. A few common signs that you’re developing an Adderall addiction include:

  • Needing higher doses to feel the same effects
  • Experiencing withdrawal symptoms such as fatigue or depression when not using
  • Neglecting responsibilities, relationships, or self-care due to Adderall use
  • Wanting to stop but being unable to do so without assistance

The sooner you start treatment, the less chance of the long-term effects of Adderall causing permanent damage to your body.

Addressing Adderall® Addiction and Side Effects With an Effective Treatment Plan

Recovery from Adderall addiction is possible with the right treatment plan. At Nurture Nexus Recovery, we offer comprehensive support tailored to each individual’s needs. Our treatment programs typically include a combination of medication-assisted treatment, behavioral therapy, and holistic care.13

Once the initial medical examination is conducted, patients carry forward with the following treatments:

  • Individual counseling, group therapy, and other evidence-based approaches. These include motivational interviewing and cognitive behavioral therapy (CBT) to address the psychological roots of addiction. 
  • This is followed up with family therapy, and other supportive approaches to build proper coping mechanisms.

However, treatment doesn’t end there. If you are experiencing the effects of abuse of Adderall, our intensive outpatient and partial hospitalization programs can help you revisit your prescription. Our medical team will be able to assess if Adderall is impacting you negatively and how to help you feel better.

Is It Common To Relapse During Adderall® Treatment?

Yes, relapsing during Adderall addiction treatment is very common. Most people develop addictive behaviors around prescription drugs because of the positive outcomes they bring. They are used to enhance performance and better results at work or school. 

Get Started With Texas’s Top Adderall® Addiction Treatment

Adderall may begin as a solution, but abuse of the medication can lead to dependence, long-term effects, and addiction. At Nurture Nexus Recovery, we specialize in compassionate, personalized addiction treatment right here in Texas. 

Our medical team is ready to help you reclaim your life with proven therapies and a supportive community. Call us at (214) 838-7488 or contact us to get the help you need.

FAQs on The Long-Term Effects of Adderall®

How Many Years Should You Take Adderall®?

There is no set timeline for how long you should take Adderall. Most people with ADHD and similar disorders are prescribed the medication for decades. However, long-term Adderall use should be closely monitored by a medical professional and assessed at regular intervals.

Do the Effects of Adderall® Go Away​?

Yes, if Adderall is taken according to the prescription, any side effects eventually go away with the discontinuation or readjustment of the drug. However, Adderall abuse tends to cause severe damage to the body, which can take years to heal.

How Long Does It Take to Recover From Adderall® Withdrawal?

Most people tend to get over Adderall withdrawal after 5 days of the last dose, but for some, it can last as long as 3 weeks. 

Is Adderall® Hard on Your Body?

Yes, Adderall is particularly hard on the body if it isn’t taken according to a professional’s recommendations. 

Can You Get Addicted to Adderall®?

Yes, since it’s a stimulant, Adderall has a potential for addiction. It can become harder to correct addictive behavior once the body has built a dependence on the stimulant.

What Are the Effects of Adderall® on Someone Without ADHD​?

Adderall can become habit-forming for those who don’t have ADHD and can even lead to side effects like increased heartbeat, excessive temperature, stomach issues, and mood swings. 

Does Adderall® Affect Your Memory Long-Term?

Yes, long-term Adderall abuse can interfere with the brain’s dopamine production and response. This impacts memory formation and retention in the long term.

Additional Resources

  1. How Long Does Adderall Stay in Your System?
  2. How to Treat Drug Addiction: Methods, Support, and Relapse Prevention
  3. Finding the Best Addiction Treatment Programs Near Me: A Comprehensive Guide

 

Adderall addiction help
Get Adderall Addiction Help Today!

 

  1. National Institute on Drug Abuse. What is the scope of prescription drug misuse in the United States? [Internet]. National Institute on Drug Abuse. 2020 [cited 2025 Jul 25]. Available from: https://nida.nih.gov/publications/research-reports/misuse-prescription-drugs/what-scope-prescription-drug-misuse
  2. Berman SM, Kuczenski R, McCracken JT, London ED. Potential adverse effects of amphetamine treatment on brain and behavior: a review. Molecular Psychiatry [Internet]. 2008 Aug 12 [cited 2025 Jul 29];14(2):123–42. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670101/
  3. Spencer TJ, Brown A, Seidman LJ, Valera EM, Makris N, Lomedico A, et al. Effect of Psychostimulants on Brain Structure and Function in ADHD. The Journal of Clinical Psychiatry [Internet]. 2013 Sep 15 [cited 2025 Jul 29];74(09):902–17. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3801446/
  4. Corkum P, Begum EA, Rusak B, Malgorzata Rajda, Shea S, MacPherson M, et al. The Effects of Extended-Release Stimulant Medication on Sleep in Children with ADHD. Journal of the Canadian Academy of Child and Adolescent Psychiatry [Internet]. 2020 Mar [cited 2025 Jul 29];29(1):33. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC7065567/
  5. Lewars J, Wiarda KP. Amphetamine-Dextroamphetamine-Induced Cardiomyopathy, an Emerging Cause of Heart Failure in Young Patient Populations: A Case Study Involving the Study Drug. Cureus [Internet]. 2023 Jun 25 [cited 2025 Jul 29];15(6). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368484/
  6. Shoar NS, Marwaha R, Molla M. Dextroamphetamine-Amphetamine [Internet]. Nih.gov. StatPearls Publishing; 2023 [cited 2025 Jul 29]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK507808/
  7. Poulton AS, Bui Q, Melzer E, Evans R. Stimulant medication effects on growth and bone age in children with attention-deficit/hyperactivity disorder. International Clinical Psychopharmacology. 2016 Mar;31(2):93–9.
  8. Oakley AM, Krishnamurthy K. Stevens Johnson Syndrome (Toxic Epidermal Necrolysis) [Internet]. PubMed. Treasure Island (FL): StatPearls Publishing; 2023 [cited 2025 Jul 29]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459323/
  9. Nanda A, Sai L, Sambe HG, Yasir M, Eyn R, Gogikar A, et al. Adverse Effects of Stimulant Interventions for Attention Deficit Hyperactivity Disorder (ADHD): A Comprehensive Systematic Review. Cureus [Internet]. 2023 Sep 26 [cited 2025 Jul 29];15(9). Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC10601982/
  10. Weyandt L, White T, Gudmundsdottir B, Nitenson A, Rathkey E, De Leon K, et al. Neurocognitive, Autonomic, and Mood Effects of Adderall: A Pilot Study of Healthy College Students. Pharmacy [Internet]. 2018 Jun 27 [cited 2025 Jul 29];6(3):58. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC6165228/
  11. Lakhan SE, Kirchgessner A. Prescription stimulants in individuals with and without attention deficit hyperactivity disorder: misuse, cognitive impact, and adverse effects. Brain and Behavior [Internet]. 2012 Jul 23 [cited 2025 Jul 29];2(5):661–77. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC3489818/
  12. Khoramizadeh M, Effatpanah M, Mostaghimi A, Rezaei M, Mahjoub A, Shishehgar S. Treatment of amphetamine abuse/use disorder: a systematic review of a recent health concern. Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences [Internet]. 2019 Dec 1 [cited 2025 Jul 29];27(2):743–53. Available from: https://pubmed.ncbi.nlm.nih.gov/31228128/
  13. Harada T, Tsutomi H, Mori R, Wilson DB. Cognitive-behavioural treatment for amphetamine-type stimulants (ATS)-use disorders. Cochrane Database of Systematic Reviews [Internet]. 2018 Dec 22 [cited 2025 Jul 29];12. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC6516990/
  14. Spiller HA, Hays HL, Aleguas A. Overdose of drugs for attention-deficit hyperactivity disorder: clinical presentation, mechanisms of toxicity, and management. CNS drugs [Internet]. 2013 Jul 1 [cited 2025 Jul 29];27(7):531–43. Available from: https://www.ncbi.nlm.nih.gov/pubmed/23757186
  1. National Institute on Drug Abuse. What is the scope of prescription drug misuse in the United States? [Internet]. National Institute on Drug Abuse. 2020 [cited 2025 Jul 25]. Available from: https://nida.nih.gov/publications/research-reports/misuse-prescription-drugs/what-scope-prescription-drug-misuse
  2. Berman SM, Kuczenski R, McCracken JT, London ED. Potential adverse effects of amphetamine treatment on brain and behavior: a review. Molecular Psychiatry [Internet]. 2008 Aug 12 [cited 2025 Jul 29];14(2):123–42. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670101/
  3. Spencer TJ, Brown A, Seidman LJ, Valera EM, Makris N, Lomedico A, et al. Effect of Psychostimulants on Brain Structure and Function in ADHD. The Journal of Clinical Psychiatry [Internet]. 2013 Sep 15 [cited 2025 Jul 29];74(09):902–17. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3801446/
  4. Corkum P, Begum EA, Rusak B, Malgorzata Rajda, Shea S, MacPherson M, et al. The Effects of Extended-Release Stimulant Medication on Sleep in Children with ADHD. Journal of the Canadian Academy of Child and Adolescent Psychiatry [Internet]. 2020 Mar [cited 2025 Jul 29];29(1):33. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC7065567/
  5. Lewars J, Wiarda KP. Amphetamine-Dextroamphetamine-Induced Cardiomyopathy, an Emerging Cause of Heart Failure in Young Patient Populations: A Case Study Involving the Study Drug. Cureus [Internet]. 2023 Jun 25 [cited 2025 Jul 29];15(6). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368484/
  6. Shoar NS, Marwaha R, Molla M. Dextroamphetamine-Amphetamine [Internet]. Nih.gov. StatPearls Publishing; 2023 [cited 2025 Jul 29]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK507808/
  7. Poulton AS, Bui Q, Melzer E, Evans R. Stimulant medication effects on growth and bone age in children with attention-deficit/hyperactivity disorder. International Clinical Psychopharmacology. 2016 Mar;31(2):93–9.
  8. Oakley AM, Krishnamurthy K. Stevens Johnson Syndrome (Toxic Epidermal Necrolysis) [Internet]. PubMed. Treasure Island (FL): StatPearls Publishing; 2023 [cited 2025 Jul 29]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459323/
  9. Nanda A, Sai L, Sambe HG, Yasir M, Eyn R, Gogikar A, et al. Adverse Effects of Stimulant Interventions for Attention Deficit Hyperactivity Disorder (ADHD): A Comprehensive Systematic Review. Cureus [Internet]. 2023 Sep 26 [cited 2025 Jul 29];15(9). Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC10601982/
  10. Weyandt L, White T, Gudmundsdottir B, Nitenson A, Rathkey E, De Leon K, et al. Neurocognitive, Autonomic, and Mood Effects of Adderall: A Pilot Study of Healthy College Students. Pharmacy [Internet]. 2018 Jun 27 [cited 2025 Jul 29];6(3):58. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC6165228/
  11. Lakhan SE, Kirchgessner A. Prescription stimulants in individuals with and without attention deficit hyperactivity disorder: misuse, cognitive impact, and adverse effects. Brain and Behavior [Internet]. 2012 Jul 23 [cited 2025 Jul 29];2(5):661–77. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC3489818/
  12. Khoramizadeh M, Effatpanah M, Mostaghimi A, Rezaei M, Mahjoub A, Shishehgar S. Treatment of amphetamine abuse/use disorder: a systematic review of a recent health concern. Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences [Internet]. 2019 Dec 1 [cited 2025 Jul 29];27(2):743–53. Available from: https://pubmed.ncbi.nlm.nih.gov/31228128/
  13. Harada T, Tsutomi H, Mori R, Wilson DB. Cognitive-behavioural treatment for amphetamine-type stimulants (ATS)-use disorders. Cochrane Database of Systematic Reviews [Internet]. 2018 Dec 22 [cited 2025 Jul 29];12. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC6516990/
  14. Spiller HA, Hays HL, Aleguas A. Overdose of drugs for attention-deficit hyperactivity disorder: clinical presentation, mechanisms of toxicity, and management. CNS drugs [Internet]. 2013 Jul 1 [cited 2025 Jul 29];27(7):531–43. Available from: https://www.ncbi.nlm.nih.gov/pubmed/23757186