How Long Does Gabapentin Stay in Your System?

How Long Does Gabapentin Stay in Your System?

Table of Contents

When it comes to addiction, prescription medications like Gabapentin might not be a focus for some treatment centers. But, if you’re wondering how long Gabapentin stays in your system, rest assured, it’s only for 48 hours since the last dose.1 

Clinics don’t usually test your hair strands for Gabapentin, but if they do, they might detect traces up to 90 days later. However, any detection of Gabapentin on tests isn’t a reason to worry since this medication is commonly prescribed to treat epilepsy, nerve pain, and shingles.2

If you feel you or a loved one is developing a Gabapentin addiction, Nurture Nexus Recovery Center can help. We offer evidence-based prescription drug addiction treatment and are just a call away!

How Long Can Gabapentin Stay in Your Body?

Although Gabapentin stops affecting you after 48 hours since the last dose, it can still be found in traces in the body3, depending on where you look. 

Saliva

Gabapentin is undetectable in saliva or swab tests for most standard test kits.

Blood

A blood sample can show traces of Gabapentin up until 5-7 hours since its last dose.

Urine

Urine samples can test positive for Gabapentin up to 4 days after the last dose.

Hair

Hair samples can store Gabapentin for up to 90 days since its last use. 

gabapentin withdrawal timeline
Timeline for Gabapentin Metabolism in the Body

 

What is The Half-Life of Gabapentin?

The half-life of Gabapentin refers to the amount of time the body takes to metabolize or eliminate half of a Gabapentin dose. This time period is roughly around 5-7 hours, depending on your body’s natural metabolic rate.4

Suppose you take 5mg of Gabapentin at 12 pm. By 7 pm, your body would have eliminated 2.5mg of the dose, and so forth, until it is fully excreted. Knowing Gabapentin’s half-life is important when estimating how long it’ll take to fully detox from the prescription drug.

Understanding Gabapentin Metabolism in the Body

Unlike most drugs that are metabolized in the liver, Gabapentin is not metabolized significantly anywhere in the body but is excreted in the kidneys. The drug is absorbed in the small intestine via the saturable L-amino acid transport system and remains unchanged in the bloodstream.5 It bypasses the liver and is excreted via the kidneys as a whole.

5 Factors That Influence How Long Gabapentin Stays in Your Body

Although Gabapentin stays in the body for 36-48 hours, there are certain factors that can cause it to linger for longer:

1. Age

As the body ages, metabolism and kidney efficiency tend to slow down. Older individuals often take longer to clear medications like Gabapentin.6

2. Overall Health

Overall health impacts how well the body’s metabolism functions. People with chronic illnesses, poor nutrition, or weakened immune systems may metabolize Gabapentin more slowly.

3. Kidney Function

Since Gabapentin is passed through the kidneys, if someone has an impaired renal system, they may take longer to clear the medication from their body.7

4. Drug Usage

Someone who has been on a high daily dose or has used the drug for months will have more of it built up in their system than a person who only took a small amount for a short period.

5. Drug Interactions

Gabapentin is sometimes prescribed alongside other medications. Certain drugs may slow down their absorption or elimination8, which can make them linger in the system.

 

Expert Opinion on Gabapentin Use for Chronic Illnesses

“Gabapentin must be used strictly in accordance with your healthcare provider’s prescription and instructions. Misuse of the medication can lead to side effects, dependence, and reduced effectiveness. Moreover, the timing and dosage of the drug should be consistent with your doctor’s orders when managing conditions like neuropathic pain or seizures.”

-Dr. Taiye Popoola

 

Is Gabapentin an Addictive Prescription Drug?

Although it was originally developed as an anticonvulsant, Gabapentin is now prescribed for nerve pain, restless leg syndrome, and even anxiety. While the medication itself does not carry the same high risk of dependence as opioids or benzodiazepines, research shows that misuse can occur.9

Individuals who have been prescribed Gabapentin may take higher or more frequent doses to feel a prolonged sense of calm or euphoria. A potential dependence on the drug is likely to develop if the patient was in extensive pain and relying on the medication for relief.

The risk increases when Gabapentin is combined with other central nervous system depressants such as alcohol, opioids, or sedatives. Overall, Gabapentin abuse is seen to occur in both prescription patients and those who use it illicitly. That’s why treating an addiction to Gabapentin is so important.

Side Effects of Gabapentin Use

Some of the most common side effects of Gabapentin10 use are:

  • Feeling sleepy
  • Dry mouth
  • Diarrhea
  • Weight gain
  • Headaches
  • Memory loss
  • Mood changes
  • Inflammation

Signs of Gabapentin Addiction

Since Gabapentin isn’t an actively addictive drug, the signs of its addiction11 aren’t very easy to pick up on. However, if you or someone you know has been taking Gabapentin for a long period, watch out for these symptoms:

  • Excessive depression
  • Suicidal thoughts
  • Trouble with coordination
  • Difficulty speaking
  • Tremors (especially in hands)
  • Increased anxiety
  • Changes in mood
  • Unusual forgetfulness 
  • Issues with balance
  • Sleep problems

What Does Gabapentin Withdrawal Look Like

Gabapentin isn’t the type of medication that can be cut off immediately. Its withdrawal period lasts anywhere from 12 hours to a week. Once your body has developed a dependence on the drug, you may experience these withdrawal symptoms12 after your last dose:

  • Sensitivity to light
  • Irregular heartbeat
  • Excessive sweating
  • Headaches & dizziness
  • Restlessness & tremors
  • Increased nausea
  • Fatigue
  • Body pain
  • Insomnia & sleep issues

Treatment Options for Gabapentin Addiction in Texas

Nurture Nexus Recovery Center offers flexible treatment for addiction to prescription drugs in Texas. Our treatment programs for Gabapentin include:

Outpatient  Program

The outpatient program provides flexible 1-3 hour sessions up to 3 days a week for those struggling with Gabapentin dependence or mild addiction.

Intensive Outpatient Program

Choose an approach focused on long-term recovery from Gabapentin addiction that mainly consists of intensive outpatient program sessions up to 6 hours a day, 3-5 days a week.

Partial Hospitalization Program

A partial hospitalization program provides medical supervision during treatment for 8 hours a day for 3-5 days a week. It is best suited to patients who require extensive care.

Medication-Assisted Treatment

For patients struggling with co-occurring mental health disorders, we provide medication-assisted treatment to treat Gabapentin addiction and other symptoms.

(214) 838-7488

Choose Texas’s Top Gabapentin Addiction Treatment Provider

It is easy to fall into Gabapentin abuse even when you’re taking the medication according to your doctor’s directions. Such a situation can quickly turn into an addiction if left unchecked. At Nurture Nexus Recovery, we specialize in compassionate, personalized addiction treatment right here in Texas. 

Our medical team is ready to help you reclaim your life with proven therapies and a supportive community. Call us at (214) 838-7488 or contact us to get the help you need.

FAQs

How Long Does Gabapentin Stop Nerve Pain?

Gabapentin is a solution for both chronic and acute nerve pain. Within the first two weeks, you may notice the effects last from one dose to another, but with prolonged use, it stops nerve pain for longer.

What Is Gabapentin Used For?

Gabapentin is a prescription medication primarily used as an anticonvulsant. However, it is also used for treatment of nerve pain, joint pain, anxiety, shingles, and other conditions.

Can You Take Gabapentin with Clonazepam together?

No, you should not take Gabapentin in combination with Clonazepam. When these two medications are taken together, there is a greater risk of respiratory and CNS depression.

What Is the Classification of Gabapentin?

On a federal level, Gabapentin is not classified as a controlled substance by the DEA. However, some states, like Kentucky, have given it the classification of a Schedule V controlled substance.

Can Gabapentin Cause Migraines?

Yes, migraines and headaches are common side effects of Gabapentin use. These side effects usually subside within two weeks of use.

Additional Resources

  1. How to Treat Drug Addiction: Methods, Support, and Relapse Prevention
  2. Finding the Best Addiction Treatment Programs Near Me: A Comprehensive Guide
  3. How To Find a Suboxone® Doctor Near Me? 5 Things To Look For
  4. Finding a Suboxone Clinic Near Me: 7 Things to Look For

 

Gabapentin withdrawal help
Get Gabapentin Withdrawal Relief Today

 

  1. Yasaei R, Katta S, Saadabadi A. Gabapentin [Internet]. PubMed. Treasure Island (FL): StatPearls Publishing; 2024 [cited 2025 Aug 22]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK493228/
  2. Peckham AM, Evoy KE, Ochs L, Covvey JR. Gabapentin for Off-Label Use: Evidence-Based or Cause for Concern? Substance Abuse: Research and Treatment [Internet]. 2018 Jan [cited 2025 Aug 22];12(1). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153543/
  3. Swearingen D, Aronoff GM, Ciric S, Lal R. Pharmacokinetics of immediate release, extended release, and gastric retentive gabapentin formulations in healthy adults. Int Journal of Clinical Pharmacology and Therapeutics [Internet]. 2018 May 1 [cited 2025 Aug 22];56(05):231–8. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC5914156/
  4. McLean MJ. Clinical pharmacokinetics of gabapentin. Neurology [Internet]. 1994 Jun 1 [cited 2025 Aug 22];44(6):17–22. Available from: https://pubmed.ncbi.nlm.nih.gov/8022536/
  5. Chincholkar M. Gabapentinoids: pharmacokinetics, pharmacodynamics and considerations for clinical practice. British Journal of Pain [Internet]. 2020 Mar 13 [cited 2025 Aug 22];14(2):104–14. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC7265598/
  6. Conway JM, Eberly LE, Collins JF, Macias FM, Ramsay RE, Leppik IE, et al. Factors in Variability of Serial Gabapentin Concentrations in Elderly Patients with Epilepsy. Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy [Internet]. 2017 Aug 12 [cited 2025 Aug 22];37(10):1197–203. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC9949609/
  7. Miller A, Price G. Gabapentin Toxicity in Renal Failure: The Importance of Dose Adjustment. Pain Medicine [Internet]. 2009 Jan [cited 2025 Aug 22];10(1):190–2. Available from: https://pubmed.ncbi.nlm.nih.gov/18721173/
  8. Quintero GC. Review about gabapentin misuse, interactions, contraindications and side effects. Journal of Experimental Pharmacology [Internet]. 2017 Feb [cited 2025 Aug 22];Volume 9:13–21. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC5308580/
  9. Gomes T, Juurlink DN, Antoniou T, Mamdani MM, Paterson JM, van den Brink W. Gabapentin, opioids, and the risk of opioid-related death: A population-based nested case–control study. Tsai AC, editor. PLOS Medicine [Internet]. 2017 Oct 3 [cited 2025 Aug 22];14(10). Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC5626029/
  10. Nwankwo A, Dhanalakshmi Koyyalagunta, Huh B, Ryan Steven D’Souza, Javed S. A comprehensive review of the typical and atypical side effects of gabapentin. Pain Practice [Internet]. 2024 Jul 1 [cited 2025 Aug 22];24(8). Available from: https://pubmed.ncbi.nlm.nih.gov/38949515/
  11. Althobaiti YS, Alghorabi A, Alshehri FS, Baothman B, Almalki AH, Alsaab HO, et al. Gabapentin-induced drug-seeking-like behavior: a potential role for the dopaminergic system. Scientific Reports [Internet]. 2020 Jun 26 [cited 2025 Aug 22];10(1). Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC7320158/
  12. Hellwig TR, Hammerquist R, Termaat J. Withdrawal symptoms after gabapentin discontinuation. American Journal of Health-System Pharmacy [Internet]. 2010 Jun 1 [cited 2025 Aug 22];67(11):910–2. Available from: https://pubmed.ncbi.nlm.nih.gov/20484214/
  1. Yasaei R, Katta S, Saadabadi A. Gabapentin [Internet]. PubMed. Treasure Island (FL): StatPearls Publishing; 2024 [cited 2025 Aug 22]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK493228/
  2. Peckham AM, Evoy KE, Ochs L, Covvey JR. Gabapentin for Off-Label Use: Evidence-Based or Cause for Concern? Substance Abuse: Research and Treatment [Internet]. 2018 Jan [cited 2025 Aug 22];12(1). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153543/
  3. Swearingen D, Aronoff GM, Ciric S, Lal R. Pharmacokinetics of immediate release, extended release, and gastric retentive gabapentin formulations in healthy adults. Int Journal of Clinical Pharmacology and Therapeutics [Internet]. 2018 May 1 [cited 2025 Aug 22];56(05):231–8. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC5914156/
  4. McLean MJ. Clinical pharmacokinetics of gabapentin. Neurology [Internet]. 1994 Jun 1 [cited 2025 Aug 22];44(6):17–22. Available from: https://pubmed.ncbi.nlm.nih.gov/8022536/
  5. Chincholkar M. Gabapentinoids: pharmacokinetics, pharmacodynamics and considerations for clinical practice. British Journal of Pain [Internet]. 2020 Mar 13 [cited 2025 Aug 22];14(2):104–14. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC7265598/
  6. Conway JM, Eberly LE, Collins JF, Macias FM, Ramsay RE, Leppik IE, et al. Factors in Variability of Serial Gabapentin Concentrations in Elderly Patients with Epilepsy. Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy [Internet]. 2017 Aug 12 [cited 2025 Aug 22];37(10):1197–203. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC9949609/
  7. Miller A, Price G. Gabapentin Toxicity in Renal Failure: The Importance of Dose Adjustment. Pain Medicine [Internet]. 2009 Jan [cited 2025 Aug 22];10(1):190–2. Available from: https://pubmed.ncbi.nlm.nih.gov/18721173/
  8. Quintero GC. Review about gabapentin misuse, interactions, contraindications and side effects. Journal of Experimental Pharmacology [Internet]. 2017 Feb [cited 2025 Aug 22];Volume 9:13–21. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC5308580/
  9. Gomes T, Juurlink DN, Antoniou T, Mamdani MM, Paterson JM, van den Brink W. Gabapentin, opioids, and the risk of opioid-related death: A population-based nested case–control study. Tsai AC, editor. PLOS Medicine [Internet]. 2017 Oct 3 [cited 2025 Aug 22];14(10). Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC5626029/
  10. Nwankwo A, Dhanalakshmi Koyyalagunta, Huh B, Ryan Steven D’Souza, Javed S. A comprehensive review of the typical and atypical side effects of gabapentin. Pain Practice [Internet]. 2024 Jul 1 [cited 2025 Aug 22];24(8). Available from: https://pubmed.ncbi.nlm.nih.gov/38949515/
  11. Althobaiti YS, Alghorabi A, Alshehri FS, Baothman B, Almalki AH, Alsaab HO, et al. Gabapentin-induced drug-seeking-like behavior: a potential role for the dopaminergic system. Scientific Reports [Internet]. 2020 Jun 26 [cited 2025 Aug 22];10(1). Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC7320158/
  12. Hellwig TR, Hammerquist R, Termaat J. Withdrawal symptoms after gabapentin discontinuation. American Journal of Health-System Pharmacy [Internet]. 2010 Jun 1 [cited 2025 Aug 22];67(11):910–2. Available from: https://pubmed.ncbi.nlm.nih.gov/20484214/